The Mitochondrial Culprit Behind Your Low Energy Levels

What if I told you mitochondria's real power goes way beyond biology class and straight into your energy, metabolism, and longevity?

Feb 26, 2025

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3 minutes

Pop Quiz. Fill in the blank: “Mitochondria is the _____ of the cell.”

  1. Home
  2. Battery
  3. Powerhouse

If you took high school biology (and like me spent hours creating posters of the cell with different organelles!) you almost definitely remember mitochondria as the “powerhouse” of the cell.

Back in the day, we thought mitochondria just ran the engines. But today, these tiny cellular engines are at the forefront of research and development in health and medical science—and for good reason.

Healthy, energized mitochondria are linked with longevity and vitality, while depleted, senescent mitochondria are associated with (you guessed it!) aging and disease. And when these powerhouses falter? It can lead to a slew of symptoms:

  • Brain fog & memory issues
  • Persistent fatigue (despite rest)
  • Slower metabolism & weight gain
  • Muscle weakness & slow recovery
  • Increased inflammation—leading to inflammaging

What triggers this mitochondrial decline? Aside from the obvious—aging—it could also be from chronic stress, poor diet, inflammation, and toxin exposure (Cell Metabolism, 2022).

The good news: Science-backed strategies can naturally boost mitochondrial health. While supplements do exist, let’s focus on the lifestyle ways you can fuel these powerhouses (that don’t require a stroll down the supplement aisle):

  1. Prioritize Nutrient-Dense Foods

Mitochondria convert nutrients into adenosine triphosphate (ATP)—your body’s energy currency—but not all foods fuel this process equally. Here are the key vitamins and minerals that do:  

  • Coenzyme Q10 (CoQ10) supports mitochondrial energy transfer.
    • Best Sources: Salmon, spinach, and nuts (The Journal of Clinical Investigation, 2021).
  • Magnesium is required for ATP activation.
    • Best Sources: Avocados, almonds, and leafy greens.
  • B Vitamins convert food into energy.
    • Best Sources: Eggs, lentils, and fortified grains.
  • Omega-3s support mitochondrial membranes.
    • Best Sources: Fatty fish, flaxseeds, and walnuts.
  1. Engage in Mitochondria-Boosting Exercise

Just as your body needs movement, your mitochondria crave physical activity to thrive. Exercise is a powerful stimulus for mitochondrial regeneration and efficiency (particularly these workouts):

  • High-intensity interval training (HIIT) and strength training stimulate mitochondrial biogenesis—creating new mitochondria (Science Translational Medicine, 2020).
    • Think: Sprint intervals, circuit training, and progressive resistance work  
  • Zone 2 cardio (steady-state exercise at 60-70% max heart rate) improves mitochondrial efficiency and fat metabolism, as does more intense cardio.
    • Think: Brisk walking, easy cycling, or jogging—any activity where you can hold a conversation
  1. Reduce Oxidative Stress & Inflammation

The secret mitochondrial killer? Excess oxidative stress—which heavily impairs ATP production. Fortunately, you can combat this with:

  • Antioxidant-rich foods
    • Best Sources: Blueberries, turmeric, dark chocolate.
  • Glutathione support
    • Best Sources: Garlic, onions, and cruciferous vegetables—all sulfur-rich foods!
  • Polyphenols (which protect the mitochondria).
    • Best Sources: Green tea, resveratrol from grapes, and olive oil (Nutrients, 2022).

While these foods combat oxidative stress, you can also avoid it in the first place by restricting ultra-processed foods, refined sugars, and excessive alcohol from your diet.

Lastly, sleep. Mitochondria also need rest to recharge and do their cellular jobs well. Shoot for 7-9 hours every night (not just on weekends). And yes, I said 7-9 hours!

After reading this, you might be thinking: “This is great, but…are you sure I can’t just replenish my mitochondria with supplements?” Well, I’ll be answering that exact question (in full scientific detail) in an upcoming issue of Ajenda. Stay tuned!

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